Healthcare Professionals’ Perceptions of Integrating Digital Technologies and Molecular Therapies in Clinical Trials
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Abstract
The integration of digital technologies and new molecular therapies in drug development has brought both opportunities and challenges in clinical practice. While much research has focused on the technical and procedural aspects of these innovations, there is limited understanding of the subjective experiences of healthcare professionals navigating these changes. This study addresses the knowledge gap regarding how professionals experience and interpret the integration of digital tools and novel therapies in clinical trials. We adopt a descriptive phenomenological approach (Colaizzi’s method) to explore the lived experiences of healthcare professionals. Data were collected through in-depth semi-structured interviews with 12 participants, comprising 7 physicians, 3 clinical pharmacists, and 2 clinical trial coordinators. The participants ranged in age from 32 to 54 years (average 42), with 6 males and 6 females, and an average professional experience of 11.5 years in clinical research. All interviews were audio-recorded, transcribed verbatim, and subjected to a three-stage coding process (open, axial, and selective coding) to identify core themes. Credibility was ensured through member checking and peer debriefing, while triangulation of data sources enhanced validity. Through this process, four key themes emerged: (1) enthusiasm toward improved patient monitoring and real-time data access; (2) resistance due to steep learning curves in adopting digital platforms; (3) concerns over data security, regulatory compliance, and patient safety; and (4) the emotional burden of adapting to rapid innovation while maintaining ethical responsibility. Participants highlighted the positive potential of these innovations, alongside challenges in training, data management, and patient safety. The findings contribute to a more holistic understanding of the human factors that shape the adoption of innovations in clinical practice, emphasizing the emotional and cognitive challenges faced by professionals. These insights offer valuable implications for future research and the development of more effective strategies for integrating technological advancements in clinical trials.
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