Understanding the Expectations and Challenges of Patients with Degenerative Diseases Toward Stem Cell Therapy: A Phenomenological Study of Personal Experiences
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Abstract
Regenerative medicine, particularly stem cell therapy, offers transformative potential for managing degenerative diseases by promoting tissue repair and restoration. Despite advancements in biomedical research, the subjective experiences of patients navigating these therapies remain underexplored, particularly concerning emotional, social, and financial dimensions. This study addresses this gap by investigating how patients perceive and make sense of their experiences with stem cell therapy for degenerative conditions. Using a descriptive phenomenological approach, this research uncovered three key themes: the duality of hope and uncertainty, procedural and financial concerns, and the vital role of social and familial support. Data were collected through in-depth interviews with 12 participants and analyzed thematically to identify the essence of their lived experiences. Findings highlight the interplay between patients’ aspirations and fears, as well as the critical importance of empathetic communication and supportive environments in alleviating psychological burdens. These insights enhance our understanding of patient-centered care in regenerative medicine, emphasizing the need to integrate emotional and social considerations into therapeutic frameworks. Future research could build on these findings by exploring diverse cultural and socioeconomic contexts, ultimately advancing inclusive and holistic medical practices.
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References
Al-Massri, K. F., Ahmed, L. A., & El-Abhar, H. S. (2020). Mesenchymal stem cells in chemotherapy-induced peripheral neuropathy: A new challenging approach that requires further investigations. Journal of Tissue Engineering and Regenerative Medicine, 14(1), 108–122. Scopus. https://doi.org/10.1002/term.2972
Biswas, D. D., Sethi, R., Woldeyohannes, Y., Scarrow, E. R., El Haddad, L., Lee, J., & ElMallah, M. K. (2024). Respiratory pathology in the TDP-43 transgenic mouse model of amyotrophic lateral sclerosis. Frontiers in Physiology, 15. Scopus. https://doi.org/10.3389/fphys.2024.1430875
Boespflug-Tanguy, O., Sevin, C., & Piguet, F. (2023). Gene therapy for neurodegenerative disorders in children: Dreams and realities. Archives de Pediatrie, 30(8), 8S32-8S40. Scopus. https://doi.org/10.1016/S0929-693X(23)00225-7
Deng, C., Zhou, Q., Zhang, M., Li, T., Chen, H., Xu, C., Feng, Q., Wang, X., Yin, F., Cheng, Y., & Wu, C. (2022). Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration. Advanced Science, 9(12). Scopus. https://doi.org/10.1002/advs.202105727
Haghighat, M., Iranbakhsh, A., Baharara, J., Ebadi, M., & Sotoodehnejadnematalahi, F. (2021). Effect of β-carotene on the differentiation potential of ciliary epithelium-derived MSCs isolated from mouse eyes on alginate-based scaffolds. Experimental Eye Research, 202. Scopus. https://doi.org/10.1016/j.exer.2020.108346
Lai, W.-F. (2021). Delivery of mesenchymal stem cells for tackling systemic disorders. Current Stem Cell Research and Therapy, 16(6), 640–646. Scopus. https://doi.org/10.2174/1574888X16666210118123724
Ludwig, A. L., & Gamm, D. M. (2021). Outer retinal cell replacement: Putting the pieces together. Translational Vision Science and Technology, 10(10). Scopus. https://doi.org/10.1167/TVST.10.10.15
Nabi, B., Rehman, S., Pottoo, F. H., Baboota, S., & Ali, J. (2020). Dissecting the therapeutic relevance of gene therapy in neuroaids: An evolving epidemic. Current Gene Therapy, 20(3), 174–183. Scopus. https://doi.org/10.2174/1566523220666200615151805
Noori, A., Dezfouli, M. R. M., Rajabi, S., Ganji, F., Ghezelayagh, Z., Agha, E. E., Baharvand, H., Chaleshtori, S. S., & Tahamtani, Y. (2023). Decellularized Lung Extracellular Matrix Scaffold Promotes Human Embryonic Stem Cell Differentiation towards Alveolar Progenitors. Cell Journal, 25(6), 372–382. Scopus. https://doi.org/10.22074/CELLJ.2023.563370.1148
Perna, A., Montine, K. S., White, L. R., Montine, T. J., & Cholerton, B. A. (2023). Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia. Neurotherapeutics, 20(6), 1641–1652. Scopus. https://doi.org/10.1007/s13311-023-01441-w
Plesa, A. M., Shadpour, M., Boyden, E., & Church, G. M. (2023). Transcriptomic reprogramming for neuronal age reversal. Human Genetics, 142(8), 1293–1302. Scopus. https://doi.org/10.1007/s00439-023-02529-1
Rehman, S., Nabi, B., Pottoo, F. H., Baboota, S., & Ali, J. (2020). Nanoparticle based gene therapy approach: A pioneering rebellion in the management of psychiatric disorders. Current Gene Therapy, 20(3), 164–173. Scopus. https://doi.org/10.2174/1566523220666200607185903
Ren, J., Li, C., Zhang, M., Wang, H., Xie, Y., & Tang, Y. (2021). A step-by-step refined strategy for highly efficient generation of neural progenitors and motor neurons from human pluripotent stem cells. Cells, 10(11). Scopus. https://doi.org/10.3390/cells10113087
Ru, L., Wu, N., Wei, K., Zeng, Y., Li, Q., Weng, C., Ren, C., Ren, B., Huo, D., Li, Y., Hu, X., Qin, Z., Fang, Y., Zhu, C., & Liu, Y. (2020). Improving cell survival and engraftment in vivo via layer-by-layer nanocoating of hESC-derived RPE cells. Stem Cell Research and Therapy, 11(1). Scopus. https://doi.org/10.1186/s13287-020-01986-z
Shi, J., Zhao, Y.-C., Niu, Z.-F., Fan, H.-J., Hou, S.-K., Guo, X.-Q., Sang, L., & Lv, Q. (2021). Mesenchymal stem cell-derived small extracellular vesicles in the treatment of human diseases: Progress and prospect. World Journal of Stem Cells, 13(1), 64–77. Scopus. https://doi.org/10.4252/wjsc.v13.i1.49