An Interpretative Exploration of CRISPR-Cas9 Gene Therapy Experiences in Rare Genetic Disorders
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Abstract
to correct genetic defects in rare disorders. However, limited attention has been given to how patients perceive and adapt to such interventions. This study aims to explore patients’ lived experiences and the meanings they ascribe to CRISPR-Cas9 therapy. An interpretative phenomenological approach (IPA) was employed, using semi-structured interviews with twelve participants who underwent CRISPR-Cas9 treatment. Analysis revealed four key themes: confronting uncertainty, redefining hope, negotiating identity, and navigating social acceptance. Findings show that the impacts of CRISPR therapy extend beyond clinical outcomes, encompassing psychological, emotional, and social dimensions. These insights emphasize the need for patient-centered frameworks in genomic medicine and provide ethical and research implications for integrating technological innovation with human experience..
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