Exploring Patients' Lived Experiences with New Drug Therapies for Chronic Illnesses: Understanding Perceptions, Emotional Reactions, and Social Impacts
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Abstract
The increasing reliance on pharmaceutical treatments has highlighted the need to better understand the subjective experiences of patients using new medications. While clinical studies have focused on the effectiveness of these drugs, little is known about how patients perceive, emotionally react to, and psychologically cope with their treatment regimens. Existing research often overlooks the emotional and psychological impacts that influence patients’ engagement with medication, as well as the social support that may mitigate negative responses. This study seeks to fill this gap by exploring the lived experiences of patients using new drugs for chronic conditions. Here, we employed an interpretative phenomenological approach to investigate how patients perceive the efficacy of their treatment, cope with side effects, and interact with their social environment during the treatment process. In-depth interviews were conducted with 15 patients, and data were analyzed using thematic analysis to uncover key themes related to emotional reactions, psychological coping strategies, social support systems, and treatment outcomes. The findings revealed that patients' emotional responses to side effects and the social support they receive from family, friends, and healthcare providers significantly influenced their perceptions of treatment success. These results provide valuable insights into the complexities of medication adherence and patient engagement, suggesting that a more holistic approach to treatment, which incorporates both emotional well-being and clinical dimensions, is essential. This study contributes to a deeper understanding of patient experiences, emphasizing the importance of emotional and social factors in treatment engagement, and has implications for future research aimed at improving patient-centered care and enhancing treatment outcomes.
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References
Ben-Zeev, D., Larsen, A., Attah, D. A., Obeng, K., Beaulieu, A., Asafo, S. M., Gavi, J. K., Kadakia, A., Sottie, E. Q., Ohene, S., Kola, L., Hallgren, K., Snyder, J., Collins, P. Y., & Ofori-Atta, A. (2024). Combining mHealth Technology and Pharmacotherapy to Improve Mental Health Outcomes and Reduce Human Rights Abuses in West Africa: Intervention Field Trial. JMIR Mental Health, 11(1). Scopus. https://doi.org/10.2196/53096
Betzler, I. R., Hempel, M., Mütze, U., Kölker, S., Winkler, E., Dikow, N., Garbade, S. F., Schaaf, C. P., & Brennenstuhl, H. (2024). Comparative analysis of gene and disease selection in genomic newborn screening studies. Journal of Inherited Metabolic Disease, 47(5), 945–970. Scopus. https://doi.org/10.1002/jimd.12750
Carreiras, H., & Castro, C. (2012). Qualitative methods in military studies: Research experiences and challenges (p. 194). Taylor and Francis; Scopus. https://doi.org/10.4324/9780203099223
Ciaccio, C., Dunne, J., Bever, A., Johnston, K., Kowal, S., Seetasith, A., Lloyd, A., & Mickle, A. (2024). Living with and Caring for People with Multiple Food Allergies: A Qualitative Study. Patient Preference and Adherence, 18, 1949–1960. Scopus. https://doi.org/10.2147/PPA.S466749
Daly, K. J. (2007). Qualitative methods for family studies & human development (p. 293). SAGE Publications Inc.; Scopus. https://doi.org/10.4135/9781452224800
Dupré, S., & Wille, B. (2025). Toward Theory-Based Volitional Personality Development Interventions at Work. International Journal of Selection and Assessment, 33(1). Scopus. https://doi.org/10.1111/ijsa.70000
Fife, W. (2020). Counting as a Qualitative Method: Grappling with the Reliability Issue in Ethnographic Research (p. 140). Springer International Publishing; Scopus. https://doi.org/10.1007/978-3-030-34803-8
Gyebuni, P., Salifu, Y., & Lasong, J. (2025). Clinicians’ experience with quinine-based treatment of malaria in the first trimester of pregnancy in Ghana: A phenomenological study. Malaria Journal, 24(1). Scopus. https://doi.org/10.1186/s12936-025-05342-5
Halboup, A. M., Harun, S. N., Sheikh Ghadzi, S. M. S., Syed Sulaiman, S. A. S., Ibrahim, D. A., Areqi, A. A., & Al-Ashwal, F. Y. (2025). Community pharmacists’ knowledge and experience regarding malaria management: A cross-sectional study in Hodeida, Yemen. Malaria Journal, 24(1). Scopus. https://doi.org/10.1186/s12936-025-05291-z
Hillman, W., & Radel, K. (2018). Qualitative methods in tourism research: Theory and practice (p. 294). Channel View Publications; Scopus. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050434848&partnerID=40&md5=7ea1e3f0b2027993b53f6a795804ee51
Iosifides, T. (2016). Qualitative Methods in Migration Studies: A Critical Realist Perspective (p. 266). Taylor and Francis; Scopus. https://doi.org/10.4324/9781315603124
Kawamura, Y. (2020). DOING RESEARCH IN FASHION AND DRESS: An Introduction to Qualitative Methods, 2nd edition (p. 166). Bloomsbury Publishing Plc.; Scopus. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188589040&partnerID=40&md5=b3db406659cd1ea5b20e05664bec39a3
Li, Y., Zhang, Y., Zhao, J., Bian, J., Zhao, Y., Hao, X., Liu, B., Hu, L., Liu, F., & Yang, C. (2024). Combined impact of hypoalbuminemia and pharmacogenomic variants on voriconazole trough concentration: Data from a real-life clinical setting in the Chinese population. Journal of Chemotherapy, 36(3), 179–189. Scopus. https://doi.org/10.1080/1120009X.2023.2247208
Longhofer, J., Floersch, J., & Hoy, J. (2012). Qualitative Methods for Practice Research (p. 224). Oxford University Press; Scopus. https://doi.org/10.1093/acprof:oso/9780195398472.001.0001
Lowenstein, M., Abrams, M. P., Crowe, M., Shimamoto, K., Mazzella, S., Botcheos, D., Bertocchi, J., Westfahl, S., Chertok, J., & Garcia, K. P. (2023). “Come try it out. Get your foot in the door:” Exploring patient perspectives on low-barrier treatment for opioid use disorder. Drug and Alcohol Dependence, 248. Scopus. https://doi.org/10.1016/j.drugalcdep.2023.109915
Lutz, W., & Knox, S. (2014). Quantitative and qualitative methods in psychotherapy research (p. 448). Taylor and Francis; Scopus. https://doi.org/10.4324/9780203386071
McNabb, D. E. (2015). Research methods for political science: Quantitative and qualitative methods: Second edition (p. 426). Taylor and Francis; Scopus. https://doi.org/10.4324/9781315701141
Migdal, A. B. (2018). Qualitative Methods in Quantum Theory (p. 460). CRC Press; Scopus. https://doi.org/10.1201/9780429497940
Moreno-Padilla, M., Delgado-Rodríguez, R., Moreno-Domínguez, S., & Cepeda-Benito, A. (2025). Self-Comparison With Influencers but Not General Instagram Use Moderate Upward and Downward Social Comparisons to #Fitspiration and #BodyPositive Images. Cyberpsychology, 19(2). Scopus. https://doi.org/10.5817/CP2025-2-2
Mukhlis, L. (2025a). A Phenomenological Study of Personal Spiritual Experiences in Navigating Religious Pluralism within Interfaith Communities. Irfana: Journal of Religious Studies, 1(6), 212–220.
Mukhlis, L. (2025b). Spiritual Grounds for Economic Growth: A Qualitative Exploration of Rural Indonesian Women’s Transformative Journeys Through Mosque-Led Empowerment Programs. Servina: Jurnal Pengabdian Kepada Masyarakat, 1(8), 289–298.
Mukhlis, L., & Abdullah, M. N. (2025). Hukum Keluarga Islam di Indonesia (1st ed.). Mukhlisina Revolution Center.
Mukhlis, L., Arifin, T., Ridwan, A. H., & Zulbaidah. (2024). Integrating Artificial Intelligenceand Maqāṣid al-Syarī‘ah: Revolutionizing Indonesia’s Sharia Online Trading System. Computer Fraud and Security, 2024(11), 301–309. https://doi.org/10.52710/cfs.238
Mukhlis, L., Arifin, T., Ridwan, A. H., & Zulbaidah. (2025). Reorientation of Sharia Stock Regulations: Integrating Taṣarrufāt al-Rasūl and Maqāṣid al-Sharī‘ah for Justice and Sustainability. Journal of Information Systems Engineering and Management, 10(10s), 58–66. https://doi.org/10.52783/jisem.v10i10s.1341
Mukhlis, L., Arifin, T., Ridwan, A. H., Zulbaidah, Rosadi, A., & Solehudin, E. (2025). Reformulation of Islamic Stock Law: The Application of Taṣarrufāt al-Rasūl and Maqāṣid al-Syarī‘ahto Develop a Dynamic and Sustainable Islamic Capital Market in Indonesia. Journal of Posthumanism, 5(3), 1–13. https://doi.org/10.63332/joph.v5i3.913
Mukhlis, L., Janwari, Y., & Syafe`i, R. (2023). INDONESIA STOCK EXCHANGE: THEORETICAL AND PHILOSOPHICAL ANALYSIS OF MUDHARABAH AND MUSYARAKAH CONTRACTS. Yurisprudentia: Jurnal Hukum Ekonomi, 9(2), 243–264. https://doi.org/10.24952/yurisprudentia.v9i2.8466
Mukhlis, L., Maryam, S., & Sormin, S. A. (2023). Model Pembelajaran Living History Berbasis PjBL Untuk Meningkatkan Keterampilan Histografi Mahasiswa. Jurnal Educatio FKIP UNMA, 9(4), 1800–1809. https://doi.org/10.31949/educatio.v9i4.5595
Mukhlis, L., & Saidah, Y. (2025). Dynamics of Nature-Based learning in Developing Children’s Motoricic Skills: Teacher and Parent Perspectives. HUMANISMA: Journal of Gender Studies, 9(1), 64–79. http://dx.doi.org/10.30983/humanisme.v4i2.9366
Mukhlis, L., Suradi, Janwari, Y., & Syafe`i, R. (2023). Sosialisasi Saham Syariah sebagai Instrumen Pengembangan Ekonomi Masyarakat di Badan Kontak Majelis Taklim (BKMT) Kabupaten Mandailing Natal. Jurnal Pengabdian Multidisiplin, 3(2), 2–9. https://doi.org/10.51214/japamul.v3i2.604
Nabirye, A. K., Munabi, I. G., Mubuuke, A. G., & Kiguli, S. (2025). Emotional and psychological experiences of nursing students caring for dying patients: An explorative study at a national referral hospital in Uganda. BMC Medical Education, 25(1). Scopus. https://doi.org/10.1186/s12909-025-06708-8
Nurmaganbetova, A., Akhmetova, A., Konyrbayeva, S., Saktaganova, T., Zhumasheva, S., Mongileva, N., & Kolomiets, O. (2025). Praise Strategies and Tactics in US Political Interviews with Donald Trump. International Journal for the Semiotics of Law, 38(7), 2319–2340. Scopus. https://doi.org/10.1007/s11196-025-10301-z
Shah, S. N., Donnelly, R. S., Amato, M. G., Alobaidly, M., Reyes, D. D., Hasan, S., Seger, D. L., Krier, J. B., & Bates, D. W. (2021). Clinical Utility of Pharmacogenomic Data Collected by a Health-System Biobank to Predict and Prevent Adverse Drug Events. Drug Safety, 44(5), 601–607. Scopus. https://doi.org/10.1007/s40264-021-01050-6
Sun, X., Ai, L., Ran, Y., Zhang, Y., Zhang, Q., Li, Q., Cui, Y., & Sun, L. (2022). Combined exploration of the mechanism of Sang Xing Decoction in the treatment of smoke-induced acute bronchitis from protein and metabolic levels. Biomedicine and Pharmacotherapy, 152. Scopus. https://doi.org/10.1016/j.biopha.2022.113254
Tabynov, K., Tailakova, E., Rakhmatullayeva, G., Bolatbekov, T., Lim, Y. H., Fomin, G., Babayeva, M., Valenta, R., & Tabynov, K. (2025). Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma. Npj Vaccines, 10(1). Scopus. https://doi.org/10.1038/s41541-025-01112-1
Tong, J., Yuan, J., Qin, Y., Zhu, N., Zhang, T., Zhu, X., Xu, Y., Liu, M., Zhang, J., & Sun, X. (2025). Clinicians’ experience on the effectiveness of pharmacotherapy in patients with first-episode depression: A randomized controlled trial based on pharmacogenomics. Frontiers in Pharmacology, 16. Scopus. https://doi.org/10.3389/fphar.2025.1626654
Wang, J., Shi, N., Zhao, P., Zhou, Y., Tian, J., Yang, X., Feng, J., Qiao, C., & Li, X. (2025). Comparative evaluation of bispecific antibody formats targeting PD-1 and LAG-3 for dual checkpoint blockade in cancer immunotherapy. Biomedicine and Pharmacotherapy, 192. Scopus. https://doi.org/10.1016/j.biopha.2025.118583
Wang, L.-Y., Cui, J.-J., Ouyang, Q.-Y., Zhan, Y., Wang, Y.-M., Xu, X.-Y., Yu, L.-L., Yin, H., Wang, Y., & Luo, C.-H. (2021). Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude. EPMA Journal, 12(3), 307–324. Scopus. https://doi.org/10.1007/s13167-021-00247-0
Zhaleh, K., & Estaji, M. (2025). “I feel secure, happy, and peaceful when my teacher implements justice in class”: A study of how Iranian EFL learners perceive and respond to teacher classroom justice. Humanities and Social Sciences Communications, 12(1). Scopus. https://doi.org/10.1057/s41599-025-05461-z
Zhang, M.-M., Niu, N., Zhi, X.-X., Zhu, P., Wu, B., Wu, B.-N., Meng, A.-F., & Zhao, Y. (2021). Nurses’ psychological changes and coping strategies during home isolation for the 2019 novel coronavirus in China: A qualitative study. Journal of Advanced Nursing, 77(1), 308–317. Scopus. https://doi.org/10.1111/jan.14572
Zhao, F., Gong, L., Wang, P., Chen, D., Cao, S., Yang, F., Tang, M., Meng, Y., Wang, Y., & Miao, L. (2025). Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy. Journal of Nanobiotechnology, 23(1). Scopus. https://doi.org/10.1186/s12951-025-03425-8